Endothelins-induce cyclicAMP formation in the guinea-pig trachea through an ETA receptor- and cyclooxygenase-dependent mechanism.

1. The non-selective endothelin agonist, endothelin-1 (ET-1), and the selective ETB receptor agonist, sarafotoxin-S6c (SRTX-c), contracted guinea-pig isolated trachea in a concentration-dependent manner. The EC50 value for ET-1 (11 +/- 2.1 nM) was significantly higher than that of SRTX-c (3.2 +/- 0....

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Main Authors: el-Mowafy, A. M., Abou-Mohamed, G. A.
格式: Artigo
語言:Inglês
出版: 1996
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1909710/
https://ncbi.nlm.nih.gov/pubmed/8762074
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