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A novel ETA-receptor antagonist, FR 139317, inhibits endothelin-induced contractions of guinea-pig pulmonary arteries, but not trachea.

1. The effects of a proposed endothelin-receptor antagonist, FR 139317, on the contraction induced by endothelin-1, endothelin-2 and endothelin-3, were analysed on isolated circular segments of pulmonary arteries and rings of trachea from the guinea-pig. 2. The pharmacological profiles of endothelin...

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Hlavní autoři: Cardell, L. O., Uddman, R., Edvinsson, L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 1993
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1907966/
https://ncbi.nlm.nih.gov/pubmed/8448595
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