Influence of monovalent cations on the binding of a charged and an uncharged ('carbo'-)muscarinic antagonist to muscarinic receptors.

1. The effect of the buffer concentration on binding of [3H]-N-methylscopolamine to muscarinic receptors M2 was tested in rat heart. Tracer binding was of low affinity in a 20 mM imidazole buffer (pKD 8.3), inhibited by an increase from 10 to 100 mM of the sodium phosphate buffer concentration (pKD...

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Detalhes bibliográficos
Principais autores: Hou, X., Wehrle, J., Menge, W., Ciccarelli, E., Wess, J., Mutschler, E., Lambrecht, G., Timmerman, H., Waelbroeck, M.
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1909415/
https://ncbi.nlm.nih.gov/pubmed/8851517
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