Foot-and-mouth disease virus 2A protease mediates cleavage in attenuated Sabin 3 poliovirus vectors engineered for delivery of foreign antigens.

Poliovirus vectors are being studied as potential vaccine delivery systems, with foreign genetic sequences incorporated as part of the viral genome. The foreign sequences are expressed as part of the viral polyprotein. Addition of proteolytic cleavage sites at the junction of the foreign polypeptide...

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Vydáno v:	J Virol
Hlavní autoři:	Mattion, N M, Harnish, E C, Crowley, J C, Reilly, P A
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1996
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190887/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8892938/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.11.8124-8127.1996
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