Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V(2) receptor antagonist

1 OPC-31260, a benzazepine derivative, has been studied for its ability to antagonize the binding of arginine vasopressin (AVP) to receptors in rat liver (V(1)) and kidney (V(2)) plasma membranes, for antagonism of the antidiuretic action of AVP in alcohol-anaesthetized rats and for diuretic action...

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Main Authors: Yamamura, Yoshitaka, Ogawa, Hidenori, Yamashita, Hiroshi, Chihara, Tomihiko, Miyamoto, Hisashi, Nakamura, Shigeki, Onogawa, Toshiyuki, Yamashita, Tatsuya, Hosokawa, Tetsumi, Mori, Toyoki, Tominaga, Michiaki, Yabuuchi, Youichi
Formato: Artigo
Idioma:Inglês
Publicado: 1992
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908728/
https://ncbi.nlm.nih.gov/pubmed/1387020
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