Progress toward the development of a genetically engineered attenuated hepatitis A virus vaccine.

Mutations which positively affect growth of hepatitis A virus in cell culture may negatively affect growth in vivo. Therefore, development of an attenuated vaccine for hepatitis A may require a careful balancing of mutations to produce a virus that will grow efficiently in cells suitable for vaccine...

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Main Authors: Funkhouser, A W, Raychaudhuri, G, Purcell, R H, Govindarajan, S, Elkins, R, Emerson, S U
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC190867/
https://ncbi.nlm.nih.gov/pubmed/8892918
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