Nedocromil sodium prevents in vivo generation of the eosinophilotactic substance induced by PAF but fails to antagonize its effects.

1 The intrathoracic injection of platelet activating factor (PAF) into rats induced a decrease in the pleural leucocyte numbers within 15 min, accompanied by a marked exudation, maximal 1 h later. After 6 h, concomitantly with the reduction of exudation, a marked increase in the number of mononuclea...

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Main Authors: e Silva, P. M., Martins, M. A., Castro-Faria-Neto, H. C., Bozza, P. T., Pires, A. L., Cordeiro, R. S., Vargaftig, B. B.
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908664/
https://ncbi.nlm.nih.gov/pubmed/1313729
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