A recombinant vaccinia virus encoding inducible nitric oxide synthase is attenuated in vivo.

To investigate the role of nitric oxide during vaccinia virus (VV) infection of mice, a recombinant VV encoding the inducible nitric oxide synthase (iNOS) gene (VV-HA-iNOS) was constructed. Following infection of immunocompromised or immunocompetent mice, the virus was highly attenuated compared wit...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Rolph, M S, Cowden, W B, Medveczky, C J, Ramshaw, I A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190837/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8892888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.11.7678-7685.1996
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