The effect of TYB-3823, a new antiarrhythmic drug, on sodium current in isolated cardiac cells.

1. Sodium current (INa) blockade by TYB-3823, a newly synthesized antiarrhythmic agent, was investigated in isolated single ventricular myocytes by use of the whole cell patch-clamp technique. 2. TYB-3823 blocked INa under steady-state conditions (Kd,rest = 500 microM, Kd,i = 4.9 microM), findings c...

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Autori principali: Miyamoto, J., Hisatome, I., Matsuoka, S., Kosaka, H., Kurata, Y., Tanaka, Y., Nawada, T., Kotake, H., Mashiba, H., Sato, R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1991
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908276/
https://ncbi.nlm.nih.gov/pubmed/1664763
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