Blockade of Na+ current by promethazine in guinea-pig ventricular myocytes.

1. To elucidate the antiarrhythmic mechanism of promethazine, its effects on the fast Na+ current (INa) were examined in single guinea-pig ventricular myocytes by whole-cell voltage clamp methods. 2. Promethazine blocked INa with a KD of 42.6 microM and Hill's coefficient of 1.1 at a holding po...

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Bibliografiske detaljer
Main Authors: Tanaka, H., Habuchi, Y., Nishimura, M., Sato, N., Watanabe, Y.
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1907677/
https://ncbi.nlm.nih.gov/pubmed/1327391
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