Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies.

A major hurdle to adenovirus (Ad)-mediated gene transfer is that the target issue lacks sufficient levels of receptors to mediate vector attachment via its fiber coat protein. Endothelial and smooth muscle cells are primary targets in gene therapy approaches to prevent restenosis following angioplas...

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Main Authors: Wickham, T J, Segal, D M, Roelvink, P W, Carrion, M E, Lizonova, A, Lee, G M, Kovesdi, I
Format: Artigo
Jezik:Inglês
Izdano: 1996
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC190730/
https://ncbi.nlm.nih.gov/pubmed/8794324
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