The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent.
The nef genes of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) encode a 27- to 34-kDa myristoylated protein which induces downregulation of CD4 surface levels and enhances virus infectivity. In adult macaques, Nef has been implicated in pathogenesis and disease...
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| Опубликовано в:: | J Virol |
|---|---|
| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology (ASM)
1996
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190686/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8709288/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.9.6493-6496.1996 |
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