The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent.

The nef genes of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) encode a 27- to 34-kDa myristoylated protein which induces downregulation of CD4 surface levels and enhances virus infectivity. In adult macaques, Nef has been implicated in pathogenesis and disease...

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Pubblicato in:	J Virol
Autori principali:	Luo, T, Garcia, J V
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190686/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8709288/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.9.6493-6496.1996
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