Large-population passages of vesicular stomatitis virus in interferon-treated cells select variants of only limited resistance.

Vesicular stomatitis virus (VSV) populations were repeatedly passaged in L-929 cells treated with alpha interferon (IFN-alpha) at levels of 25 U/ml. This IFN-alpha concentration induced a 99.9% inhibition of viral yield in standard infections. Analysis of viral fitness (overall replicative ability m...

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Main Authors: Novella, I S, Cilnis, M, Elena, S F, Kohn, J, Moya, A, Domingo, E, Holland, J J
Format: Artigo
Jezik:Inglês
Izdano: 1996
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC190671/
https://ncbi.nlm.nih.gov/pubmed/8709273
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