Large-population passages of vesicular stomatitis virus in interferon-treated cells select variants of only limited resistance.

Vesicular stomatitis virus (VSV) populations were repeatedly passaged in L-929 cells treated with alpha interferon (IFN-alpha) at levels of 25 U/ml. This IFN-alpha concentration induced a 99.9% inhibition of viral yield in standard infections. Analysis of viral fitness (overall replicative ability m...

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Pubblicato in:	J Virol
Autori principali:	Novella, I S, Cilnis, M, Elena, S F, Kohn, J, Moya, A, Domingo, E, Holland, J J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190671/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8709273/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.9.6414-6417.1996
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