Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95

Leucocyte adhesion deficiency (LAD) is a hereditary disorder caused by mutations in the CD18 (β2 integrin) gene. Four missense mutations have been identified in three patients. CD18(A270V) supports, at a diminished level, CD11b/CD18 (Mac-1, αMβ2 integrin) and CD11c/CD18 (p150,95, αXβ2 integrin) expr...

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Detalhes bibliográficos
Main Authors: Shaw, J M, Al-Shamkhani, A, Boxer, L A, Buckley, C D, Dodds, A W, Klein, N, Nolan, S M, Roberts, I, Roos, D, Scarth, S L, Simmons, D L, Tan, S M, Law, S K A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Immunodeficiency
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906209/
https://ncbi.nlm.nih.gov/pubmed/11703376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01661.x
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