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Cleavage site mutations in the encephalomyocarditis virus P3 region lethally abrogate the normal processing cascade.

Site-specific mutations within the proteinase 3C-dependent P3 region cleavage sequences of encephalomyocarditis virus have been constructed. The mutations altered the normal QG cleavage site dipeptide pairs of the 2C/3A, 3A/3B, 3B/3C, and 3C/3D junctions into QV, QC, QF, QY, and RG sequences. When t...

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Udgivet i:J Virol
Principais autores: Hall, D J, Palmenberg, A C
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190615/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8709217/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.9.5954-5961.1996
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