Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility.

Amino acid variation at reverse transcriptase (RT) codon 210 (generally Leu-210 to Trp [L210W], TTG-->TGG) is occasionally detected after the initiation of azidothymidine (AZT) therapy. The impact of this variation on AZT resistance and viral replication was addressed by four different approaches. T...

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Pubblicato in:	J Virol
Autori principali:	Harrigan, P R, Kinghorn, I, Bloor, S, Kemp, S D, Nájera, I, Kohli, A, Larder, B A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190612/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8709214/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.9.5930-5934.1996
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