Inhibition of p38 MAP kinase during cellular activation results in IFN-γ-dependent augmentation of IL-12 production by human monocytes/macrophages

Interleukin-12 (IL-12) is a key immunomodulatory cytokine produced by antigen-presenting cells that promotes cellular immunity and enables the generation of protective immunity against intracellular pathogens and tumours. Therefore, modulation of IL-12 activity is a primary immunotherapeutic goal. H...

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Detalhes bibliográficos
Main Authors: Marriott, J B, Clarke, I A, Dalgleish, A G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Human Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906092/
https://ncbi.nlm.nih.gov/pubmed/11472427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01574.x
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