Opsonizing antibodies (IgG1) up-regulate monocyte proinflammatory cytokines tumour necrosis factor-alpha (TNF-α) and IL-6 but not anti-inflammatory cytokine IL-10 in mycobacterial antigen-stimulated monocytes—implications for pathogenesis

Cachexia is one of the prominent features of advanced tuberculosis (TB) seen in association with increased expression of the monokine TNF-α. Several mycobacterial proteins, including PPD, stimulate TNF-α secretion from monocytes. Host factors that may play a role in cytokine expression from monocyte...

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Bibliographic Details
Main Authors: Hussain, R, Shiratsuchi, H, Phillips, M, Ellner, J, Wallis, R S
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
Subjects:
Immunity to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905980/
https://ncbi.nlm.nih.gov/pubmed/11207650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01439.x
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