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PPD-specific IgG1 antibody subclass upregulate tumour necrosis factor expression in PPD-stimulated monocytes: possible link with disease pathogenesis in tuberculosis
Cachexia is a prominent feature of advanced tuberculosis, in association with increased expression of the monokine tumour necrosis factor (TNF)-α. Monocytes, have high affinity receptors (mannose, complement and Fc γ1 and γ111) which mediate antigen uptake and subsequent cytokine activation. Several...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1905580/ https://ncbi.nlm.nih.gov/pubmed/10691916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2000.01139.x |
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