Nalaganje...
Rearrangement of the human heavy chain variable region gene V3–23 in transgenic mice generates antibodies reactive with a range of antigens on the basis of V(H)CDR3 and residues intrinsic to the heavy chain variable region
To formulate a ‘logic’ for how a single immunoglobulin variable region gene generates antibodies with different antigen specificity and polyreactivity, we analysed chimeric antibodies produced in transgenic mice carrying the germ-line human V3–23 gene, multiple diversity (D) and joining (J) gene seg...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Blackwell Science Inc
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1905971/ https://ncbi.nlm.nih.gov/pubmed/11167990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01380.x |
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