Rearrangement of the human heavy chain variable region gene V3–23 in transgenic mice generates antibodies reactive with a range of antigens on the basis of V(H)CDR3 and residues intrinsic to the heavy chain variable region

To formulate a ‘logic’ for how a single immunoglobulin variable region gene generates antibodies with different antigen specificity and polyreactivity, we analysed chimeric antibodies produced in transgenic mice carrying the germ-line human V3–23 gene, multiple diversity (D) and joining (J) gene seg...

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Detalhes bibliográficos
Main Authors: Mageed, R A, Harmer, I J, Wynn, S L, Moyes, S P, Maziak, B R, Brüggemann, M, Mackworth-Young, C G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Autoimmmunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905971/
https://ncbi.nlm.nih.gov/pubmed/11167990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01380.x
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