Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site

ANCA with specificity for proteinase 3 (PR3), a neutrophil primary granule enzyme, are of diagnostic value in Wegener's granulomatosis (WG) and certain other forms of systemic vasculitis. There is evidence to suggest that they play a pathogenic role in disease, and that the interaction of ANCA...

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Bibliographic Details
Main Authors: Griffith, M E, Coulthart, A, Pemberton, S, George, A J T, Pusey, C D
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
Subjects:
Vasculitis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905952/
https://ncbi.nlm.nih.gov/pubmed/11168015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01420.x
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