Human mast cell tryptase stimulates the release of an IL-8-dependent neutrophil chemotactic activity from human umbilical vein endothelial cells (HUVEC)

Tryptase, the major product of human mast cell activation, is a potent stimulus of vascular leakage and neutrophil accumulation in vivo in animal studies, but the mechanisms of action remain unclear. Using HUVEC cultures we have sought to investigate the potential of tryptase to alter monolayer perm...

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Autors principals: Compton, S J, Cairns, J A, Holgate, S T, Walls, A F
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2000
Matèries:
Allergy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905680/
https://ncbi.nlm.nih.gov/pubmed/10886236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2000.01271.x
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