Absence of platelet CD40L identifies patients with X-linked hyper IgM syndrome

CD40 ligand (CD40L), a membrane protein expressed on activated T cells, plays a pivotal role in B cell proliferation and differentiation. Mutations in the CD40L gene are associated with a rare immunodeficiency state, X-linked hyper IgM syndrome (XLHIGM). Recently, platelets have been described as ca...

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Autores principales: Inwald, D P, Peters, M J, Walshe, D, Jones, A, Davies, E G, Klein, N J
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2000
Materias:
Immunodeficiency
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905570/
https://ncbi.nlm.nih.gov/pubmed/10844529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2000.01235.x
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