Evidence for antigen presentation to sensitized T cells by thyroid peroxidase (TPO)-specific B cells in mice injected with fibroblasts co-expressing TPO and MHC class II

Injection of AKR/N mice with fibroblasts co-expressing MHC class II and TPO in the absence of adjuvant induces IgG-class TPO antibodies that resemble spontaneously arising human thyroid autoantibodies. We have used this model to examine the effect of iodide on TPO antibody induction as well as to an...

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Detalles Bibliográficos
Main Authors: Guo, J, Wang, Y, Rapoport, B, McLachlan, S M
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2000
Assuntos:
Endocrine Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905538/
https://ncbi.nlm.nih.gov/pubmed/10606962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2000.01087.x
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