Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1.

Kinetic analysis showed that the Ki values and the Ki/Km ratios for mutated, recombinant M184V human immunodeficiency virus type 1 reverse transcriptase (RT) for (-)2'-dideoxy-3'-thiacytidine triphosphate (3TCTP) were 35-fold higher than the equivalent values for wild-type RT but only about twice as...

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Pubblicato in:	J Virol
Autori principali:	Quan, Y, Gu, Z, Li, X, Li, Z, Morrow, C D, Wainberg, M A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190526/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8764080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.8.5642-5645.1996
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