Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation

To investigate the role of GM-CSF in asthmatic airways inflammation, we have targeted GM-CSF transgene to the airway cells in a mouse model of ovalbumin (OVA)-induced allergic airways inflammation, a model in which there is marked induction of endogenous IL-5 and IL-4 but not GM-CSF. Following intra...

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Autors principals: Lei, X-F, Ohkawara, Y, Stämpfli, M R, Gauldie, J, Croitoru, K, Jordana, M, Xing, Z
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 1998
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905049/
https://ncbi.nlm.nih.gov/pubmed/9717963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1998.00652.x
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