The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport

The yeast gene fab1 and its mammalian orthologue Pip5k3 encode the phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinases Fab1p and PIKfyve, respectively, enzymes that generates phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P(2)]. A shared feature of fab1Δ yeast cells and mammalian cells overex...

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Detalhes bibliográficos
Main Authors: Rutherford, Anna C., Traer, Colin, Wassmer, Thomas, Pattni, Krupa, Bujny, Miriam V., Carlton, Jeremy G., Stenmark, Harald, Cullen, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904490/
https://ncbi.nlm.nih.gov/pubmed/16954148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.03153
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