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Uncoupling of Hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptor

The mechanisms underlying androgen receptor (AR)-mediated progression of prostate cancer following androgen ablation have yet to be fully determined. On this basis we screened naturally occurring mutants of human AR for hormone independent activity using a yeast model system. An initial screen of 43...

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Detalhes bibliográficos
Main Authors: Robzyk, Kenneth, Oen, Handy, Buchanan, Grant, Butler, Lisa M., Tilley, Wayne, Mandal, Atin K., Rosen, Neal, Caplan., Avrom J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904484/
https://ncbi.nlm.nih.gov/pubmed/17336451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2007.01.016
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