Inhibition of topoisomerase II by ICRF-193 prevents efficient replication of herpes simplex virus type 1.
Cellular topoisomerase II is specifically inactivated by the drug ICRF-193. This compound turns topoisomerase II into a closed clamp that is unable to cleave DNA. We have investigated the effects of this inhibitor on the replication of herpes simplex virus type 1. We show that ICRF-193 at low multip...
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| Udgivet i: | J Virol |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190388/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8676478/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.7.4523-4529.1996 |
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