Inhibition of topoisomerase II by ICRF-193 prevents efficient replication of herpes simplex virus type 1.

Cellular topoisomerase II is specifically inactivated by the drug ICRF-193. This compound turns topoisomerase II into a closed clamp that is unable to cleave DNA. We have investigated the effects of this inhibitor on the replication of herpes simplex virus type 1. We show that ICRF-193 at low multip...

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Argitaratua izan da:	J Virol
Egile Nagusiak:	Hammarsten, O, Yao, X, Elias, P
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 1996
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190388/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8676478/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.7.4523-4529.1996
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