Functional implications of mutations within polyomavirus large T antigen Rb-binding domain: effects on pRb and p107 binding in vitro and immortalization activity in vivo.

In this study, we have extensively modified the Rb-binding domain of polyomavirus large T antigen. Mutant polyomavirus large T antigens were tested for their ability to bind pRb and p107 in vitro and assayed for their capacity to immortalize primary rat embryo fibroblasts in vivo. Polyomavirus large...

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Pubblicato in:	J Virol
Autori principali:	Pilon, A A, Desjardins, P, Hassell, J A, Mes-Masson, A M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190380/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8676470/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.7.4457-4465.1996
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