Functional implications of mutations within polyomavirus large T antigen Rb-binding domain: effects on pRb and p107 binding in vitro and immortalization activity in vivo.

In this study, we have extensively modified the Rb-binding domain of polyomavirus large T antigen. Mutant polyomavirus large T antigens were tested for their ability to bind pRb and p107 in vitro and assayed for their capacity to immortalize primary rat embryo fibroblasts in vivo. Polyomavirus large...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pilon, A A, Desjardins, P, Hassell, J A, Mes-Masson, A M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1996
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC190380/
https://ncbi.nlm.nih.gov/pubmed/8676470
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