A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa.

EBNA-3C can affect the LMP-1 promoter in both a positive and a negative manner through distinct DNA sequence elements. The viral transactivator EBNA-2 normally binds DNA indirectly via Jkappa to activate transcription, but this activation is prevented in the presence of EBNA-3C. The DNA element reco...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Zhao, B, Marshall, D R, Sample, C E
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8676443/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.7.4228-4236.1996
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