Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes.

The adenovirus E1A protein of 243 amino acids has been shown to affect a variety of cellular functions, most notably the immortalization of primary cells and the promotion of quiescent cells into S phase. The activity of E1A is derived, in part, from its association with various cellular proteins, m...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Mal, A, Piotrkowski, A, Harter, M L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190149/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8627766/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.5.2911-2921.1996
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