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In Vivo Fitness Costs of Different Gag CD8 T-Cell Escape Mutant Simian-Human Immunodeficiency Viruses for Macaques

The kinetics of immune escape and reversion depend upon the efficiency of CD8 cytotoxic T lymphocytes (CTL) and the fitness cost of escape mutations. Escape kinetics of three simian immunodeficiency virus Gag CTL epitopes in pigtail macaques were variable; those of KP9 and AF9 were faster than those...

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Main Authors: Loh, Liyen, Batten, C. Jane, Petravic, Janka, Davenport, Miles P., Kent, Stephen J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900239/
https://ncbi.nlm.nih.gov/pubmed/17344299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02763-06
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