Small Interfering RNAs against the TAR RNA Binding Protein, TRBP, a Dicer Cofactor, Inhibit Human Immunodeficiency Virus Type 1 Long Terminal Repeat Expression and Viral Production

RNA interference (RNAi) is now widely used for gene silencing in mammalian cells. The mechanism uses the RNA-induced silencing complex, in which Dicer, Ago2, and the human immunodeficiency virus type 1 (HIV-1) TAR RNA binding protein (TRBP) are the main components. TRBP is a protein that increases H...

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Autors principals: Christensen, Helen S., Daher, Aïcha, Soye, Kaitlin J., Frankel, Lisa B., Alexander, Marina R., Lainé, Sébastien, Bannwarth, Sylvie, Ong, Chi L., Chung, Sean W. L., Campbell, Shahan M., Purcell, Damian F. J., Gatignol, Anne
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900231/
https://ncbi.nlm.nih.gov/pubmed/17360756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01511-06
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