Characterization of the TRBP domain required for Dicer interaction and function in RNA interference

BACKGROUND: Dicer, Ago2 and TRBP are the minimum components of the human RNA-induced silencing complex (RISC). While Dicer and Ago2 are RNases, TRBP is the double-stranded RNA binding protein (dsRBP) that loads small interfering RNA into the RISC. TRBP binds directly to Dicer through its C-terminal...

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Main Authors: Daniels, Sylvanne M, Melendez-Peña, Carlos E, Scarborough, Robert J, Daher, Aïcha, Christensen, Helen S, El Far, Mohamed, Purcell, Damian FJ, Lainé, Sébastien, Gatignol, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685382/
https://ncbi.nlm.nih.gov/pubmed/19422693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-10-38
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