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Role of the CD8(+) Dendritic Cell Subset in Transmission of Prions

Controversial results have been observed in mouse models regarding the role of lymphoid tissues in prion pathogenesis. To investigate the role of dendritic cells (DC), we used a transgenic mouse model. In this model (CD11c-N17Rac1), a significant reduction of CD8(+) CD11c(hi) DC has been described,...

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Main Authors: Sethi, Shneh, Kerksiek, Kristen M., Brocker, Thomas, Kretzschmar, Hans
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900152/
https://ncbi.nlm.nih.gov/pubmed/17301133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02345-06
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