Kaposi's Sarcoma-Associated Herpesvirus LANA Protein Downregulates Nuclear Glycogen Synthase Kinase 3 Activity and Consequently Blocks Differentiation

The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen (LANA) protein interacts with glycogen synthase kinase 3 (GSK-3) and relocalizes GSK-3 in a manner that leads to stabilization of β-catenin and upregulation of β-catenin-responsive cell genes. The LANA-GSK-3 interact...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Jianyong, Martin, Heather, Shamay, Meir, Woodard, Crystal, Tang, Qi-Qun, Hayward, S. Diane
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900136/
https://ncbi.nlm.nih.gov/pubmed/17314169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02548-06
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