Crystal Structure of a Monomeric Form of Severe Acute Respiratory Syndrome Coronavirus Endonuclease nsp15 Suggests a Role for Hexamerization as an Allosteric Switch

Mature nonstructural protein-15 (nsp15) from the severe acute respiratory syndrome coronavirus (SARS-CoV) contains a novel uridylate-specific Mn(2+)-dependent endoribonuclease (NendoU). Structure studies of the full-length form of the obligate hexameric enzyme from two CoVs, SARS-CoV and murine hepa...

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Detalhes bibliográficos
Main Authors: Joseph, Jeremiah S., Saikatendu, Kumar Singh, Subramanian, Vanitha, Neuman, Benjamin W., Buchmeier, Michael J., Stevens, Raymond C., Kuhn, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900129/
https://ncbi.nlm.nih.gov/pubmed/17409150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02817-06
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