Induction of Apoptosis by the Severe Acute Respiratory Syndrome Coronavirus 7a Protein Is Dependent on Its Interaction with the Bcl-X(L) Protein

The severe acute respiratory syndrome coronavirus (SARS-CoV) 7a protein, which is not expressed by other known coronaviruses, can induce apoptosis in various cell lines. In this study, we show that the overexpression of Bcl-X(L), a prosurvival member of the Bcl-2 family, blocks 7a-induced apoptosis,...

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Detalhes bibliográficos
Main Authors: Tan, Ying-Xim, Tan, Timothy H. P., Lee, Marvin J.-R., Tham, Puay-Yoke, Gunalan, Vithiagaran, Druce, Julian, Birch, Chris, Catton, Mike, Fu, Nai Yang, Yu, Victor C., Tan, Yee-Joo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900074/
https://ncbi.nlm.nih.gov/pubmed/17428862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00090-07
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