Degradation of Mcl-1 by β-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization

Apoptosis is critical for embryonic development, tissue homeostasis, and tumorigenesis and is determined largely by the Bcl-2 family of antiapoptotic and prosurvival regulators. Here, we report that glycogen synthase kinase 3 (GSK-3) was required for Mcl-1 degradation, and we identified a novel mech...

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Autores principales: Ding, Qingqing, He, Xianghuo, Hsu, Jung-Mao, Xia, Weiya, Chen, Chun-Te, Li, Long-Yuan, Lee, Dung-Fang, Liu, Jaw-Ching, Zhong, Qing, Wang, Xiaodong, Hung, Mien-Chie
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900029/
https://ncbi.nlm.nih.gov/pubmed/17387146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00620-06
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