Cell-Permeating α-Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells

Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are components of the tricarboxylic acid (TCA) cycle and tumor suppressors. Loss of SDH or FH induces pseudohypoxia, a major tumor-supporting event, which is the activation of hypoxia-inducible factor (HIF) under normoxia. In SDH- or FH-defic...

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Main Authors: MacKenzie, Elaine D., Selak, Mary A., Tennant, Daniel A., Payne, Lloyd J., Crosby, Stuart, Frederiksen, Casper M., Watson, David G., Gottlieb, Eyal
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899954/
https://ncbi.nlm.nih.gov/pubmed/17325041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01927-06
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