An Acetylation/Deacetylation-SUMOylation Switch through a Phylogenetically Conserved ψKXEP Motif in the Tumor Suppressor HIC1 Regulates Transcriptional Repression Activity

Tumor suppressor HIC1 (hypermethylated in cancer 1) is a gene that is essential for mammalian development, epigenetically silenced in many human tumors, and involved in a complex pathway regulating P53 tumor suppression activity. HIC1 encodes a sequence-specific transcriptional repressor containing...

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Bibliographic Details
Main Authors: Stankovic-Valentin, Nicolas, Deltour, Sophie, Seeler, Jacob, Pinte, Sébastien, Vergoten, Gérard, Guérardel, Cateline, Dejean, Anne, Leprince, Dominique
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899900/
https://ncbi.nlm.nih.gov/pubmed/17283066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01098-06
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