Interferon-γ Sensitizes Resistant Ewing’s Sarcoma Cells to Tumor Necrosis Factor Apoptosis-Inducing Ligand-Induced Apoptosis by Up-Regulation of Caspase-8 Without Altering Chemosensitivity

Ewing’s sarcoma cells are highly susceptible to apoptosis via tumor necrosis factor apoptosis-inducing ligand (TRAIL). Resistance to TRAIL has been linked to deficient expression of caspase-8 in vitro. Here, we report on the status of caspase-8 expression in tumors from patients with Ewing’s sarcoma...

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Detalhes bibliográficos
Main Authors: Lissat, Andrej, Vraetz, Thomas, Tsokos, Maria, Klein, Ruth, Braun, Matthias, Koutelia, Nino, Fisch, Paul, Romero, Maria E., Long, Lauren, Noellke, Peter, Mackall, Crystal L., Niemeyer, Charlotte M., Kontny, Udo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899433/
https://ncbi.nlm.nih.gov/pubmed/17525260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060993
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