Optimization of Quantitative MGMT Promoter Methylation Analysis Using Pyrosequencing and Combined Bisulfite Restriction Analysis

Resistance to chemotherapy is a major complication during treatment of cancer patients. Hypermethylation of the MGMT gene alters DNA repair and is associated with longer survival of glioblastoma patients treated with alkylating agents. Therefore, MGMT promoter methylation plays an important role as...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Mikeska, Thomas, Bock, Christoph, El-Maarri, Osman, Hübner, Anika, Ehrentraut, Denise, Schramm, Johannes, Felsberg, Jörg, Kahl, Philip, Büttner, Reinhard, Pietsch, Torsten, Waha, Andreas
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Investigative Pathology 2007
נושאים:
Regular Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899414/
https://ncbi.nlm.nih.gov/pubmed/17591937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2007.060167
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