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Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Iα inhibit NO-induced cerebral dilation

Arrays of octameric peptide libraries on cellulose paper were screened by using (32)P-autophosphorylated cGMP-dependent protein kinase Iα (cGPK) to identify peptide sequences with high binding affinity for cGPK. Iterative deconvolution of every amino acid position in the peptides identified the sequ...

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Autors principals: Dostmann, Wolfgang R. G., Taylor, Mark S., Nickl, Christian K., Brayden, Joseph E., Frank, Ronald, Tegge, Werner J.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC18994/
https://ncbi.nlm.nih.gov/pubmed/11121077
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